Thursday, February 16, 2012
Find a protein using PDB explorer-describe your protein, including what disease state or other real-world application it has.
Amyloid beta-peptide (Abeta) is derived from the amyloid precursor protein. This protein is found in the synapses of neurons and helps with the growth of the neurons. When the amyloid precursor protein breaks down into amyloid beta-peptides, it becomes an issue because they can build up in the brain and cause Alzheimer's disease (AD). The Abeta is a beta-peptide fragment with a length of 42 amino acids. When the amyloid beta-peptide breaks apart from the protein, it changes shape and and turns into a long fibril. The fibrils than turn into plaques and as they build up, they cause neuronal damage which leads to AD.
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