Thursday, February 23, 2012
What knowledge have you connected with past knowledge?
"Structure determines function" is an important phrase that has been said in many biology classes. Most evidence of this is studied in diseases that are caused by denatured and misfolded proteins. For example Alzheimer's disease, Huntington's and Parkinson's are a result of misfolded proteins. This means that the code for a specific protein on the genetic sequence was not normal which resulted in a disease. The structure of the protein was altered and the function of that protein changed to cause harm in the body. Other examples may include the denature of enzymes which causes them to not do their job and not bind to their specific substrate. This would also cause the body to loose the ability to catalyze a reaction. The active site on a denatured enzyme is not normal therefore the substrate can not bind to it which would change the enzymes function.
Thursday, February 16, 2012
Find a protein using PDB explorer-describe your protein, including what disease state or other real-world application it has.
Amyloid beta-peptide (Abeta) is derived from the amyloid precursor protein. This protein is found in the synapses of neurons and helps with the growth of the neurons. When the amyloid precursor protein breaks down into amyloid beta-peptides, it becomes an issue because they can build up in the brain and cause Alzheimer's disease (AD). The Abeta is a beta-peptide fragment with a length of 42 amino acids. When the amyloid beta-peptide breaks apart from the protein, it changes shape and and turns into a long fibril. The fibrils than turn into plaques and as they build up, they cause neuronal damage which leads to AD.
Wednesday, February 8, 2012
What is BioChemistry, and how does it differ from the fields of genetics, biology, chemistry, and molecular biology.
Biochemistry is the study of living organisms and their chemical processes which determines their function. Biochemistry has many branches to it. It is the base of life sciences and brings them together on a chemical level. The study of biochemistry consists of all the cellular chemical processes that undergo cellular respiration, photosynthesis, protein synthesis,etc. Genetics differs with biochemistry because genetics focuses more on the hereditary component of living organisms. Genetics explains the inheritance of characteristics and genes of living organisms. Biology differs from biochemistry by not focusing on the chemistry part. Biology explains the living organism as a whole and it's interactions with their surroundings. Chemistry on the other hand differs from biochemistry by focusing more on the chemical processes that occur between molecules all around us. Molecular biology is the study of macromolecules that are needed for life, like proteins. It differs from biochemistry because it focuses more on the mechanisms of protein synthesis and replication of genetic information. In conclusion, biochemistry is essential in living organisms and the natural processes they undergo.
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